HLA-DPβ and susceptibility to multiple sclerosis: an analysis of Caucasoid and Japanese patient populations
AB Begovich, RC Helmuth, JR Oksenberg, K Sakai… - Human immunology, 1990 - Elsevier
Nonradioactive sequence-specific oligonucleotide (SSO) probes specific for the HLA-DPβ
locus have been used in a simple dot-blot assay to DPβ-type samples amplified by the
polymerase chain reaction (pcr) from Caucasoid (n= 24) and Japanese (n= 23) patients with
multiple sclerosis (ms) as well as ethnically matched controls. In contrast to previous reports,
no DPβ allele was found to be increased in either patient population. However, the results
do show a dramatic difference in the allele frequencies between the two control populations …
locus have been used in a simple dot-blot assay to DPβ-type samples amplified by the
polymerase chain reaction (pcr) from Caucasoid (n= 24) and Japanese (n= 23) patients with
multiple sclerosis (ms) as well as ethnically matched controls. In contrast to previous reports,
no DPβ allele was found to be increased in either patient population. However, the results
do show a dramatic difference in the allele frequencies between the two control populations …
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