Male breast cancer (MBC) is a rare hormone-driven disease often associated with obesity.
HMG-CoAR is the central enzyme of the mevalonate pathway, a molecular route deputed to
produce cholesterol and steroid-based hormones. HMG-CoAR regulates the oncogenic
Hippo transducers TAZ/YAP whose expression was previously associated with shorter
survival in MBC. 225 MBC samples were immunostained for HMG-CoAR and 124 were
considered eligible for exploring its relationship with hormone receptors (ER, PgR, AR) …

Results Relationship between HMG-CoAR, hormone receptors and Hippo transducers. For
this retrospective study, 255 MBC samples were screened for the expression of HMG-CoAR.
One hundred twenty four patients (124) were included on the basis of the eligibility criteria
described in the paragraph addressing Materials and Methods. One hundred thirty one
(131) patients were excluded for the following reasons: missing (N= 100) or ambiguous (N=
7) data on overall survival (OS), missing data on HMG-CoAR status (N= 17), missing data on …