Head or brain injuries and Alzheimer's disease: a nested case-control register study

AM Tolppanen, H Taipale, S Hartikainen - Alzheimer's & Dementia, 2017 - Elsevier
Introduction Many previous studies have been limited by self-or proxy-reported injury or
short follow-up. We investigated whether head or brain injuries are associated with
Alzheimer's disease (AD), possible modifying factors and dose-response relationship.
Methods Nested register-based case-control study of all community dwellers who received
clinically verified AD diagnosis in Finland in 2005 to 2011 (n= 70,719) and one to four
matched controls for each case (n of controls= 282,862). Results The magnitude of …
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