Higher blood harmane (1-methyl-9H-pyrido [3, 4-b] indole) concentrations correlate with lower olfactory scores in essential tremor
ED Louis, E Rios, KM Pellegrino, W Jiang… - Neurotoxicology, 2008 - Elsevier
BACKGROUND: Harmane (1-methyl-9H-pyrido [3, 4-b] indole), a neurotoxin, may be an
environmental risk factor for essential tremor (ET). Harmane and related chemicals are toxic
to the cerebellum. Whether it is through this mechanism (cerebellar toxicity) that harmane
leads to ET is unknown. Impaired olfaction may be a feature of cerebellar disease.
OBJECTIVE: To determine whether blood harmane concentrations correlate with olfactory
test scores in patients with ET. METHODS: Blood harmane concentrations were quantified …
environmental risk factor for essential tremor (ET). Harmane and related chemicals are toxic
to the cerebellum. Whether it is through this mechanism (cerebellar toxicity) that harmane
leads to ET is unknown. Impaired olfaction may be a feature of cerebellar disease.
OBJECTIVE: To determine whether blood harmane concentrations correlate with olfactory
test scores in patients with ET. METHODS: Blood harmane concentrations were quantified …
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