New biomaterials including surface modifications should undergo in vitro and in vivo
evaluation before clinical trials. The objective of our in vivo study was to evaluate the
biocompatibility of one of the newly fabricated zirconia implant surfaces, called “mds”. For
this purpose, the osseointegration of these implants was analyzed after implantation in
surgically created defects in the cranium of adult male rats. After a healing period of 28 and
56 days, respectively, bone tissue specimens containing the implants were processed and …