Homozygous typing cell-defined HLA-Dw specificities correlate better than serologically defined HLA-DR specificities with restriction elements for influenza virus …
B Fleischer, G Pawelec, P Wernet - Human Immunology, 1985 - Elsevier
Human T lymphocyte clones with specific proliferative response to influenza A virus were
derived by limiting dilution from peripheral blood lymphocytes (PBL) after in vitro stimulation
with autologous irradiated, virus-infected PBL. Four OKT3+ 4+ 8− lymphocyte clones (TLC)
that showed HLA-restricted antigen-specific proliferative responses were used for a detailed
analysis of the restriction elements for antigen presentation. None of the clones showed
alloreactivity and all required the presence on the antigen-presenting cell of HLA class II …
derived by limiting dilution from peripheral blood lymphocytes (PBL) after in vitro stimulation
with autologous irradiated, virus-infected PBL. Four OKT3+ 4+ 8− lymphocyte clones (TLC)
that showed HLA-restricted antigen-specific proliferative responses were used for a detailed
analysis of the restriction elements for antigen presentation. None of the clones showed
alloreactivity and all required the presence on the antigen-presenting cell of HLA class II …
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