[HTML][HTML] Hypodermal responses to protein synthesis inhibition induce systemic developmental arrest and AMPK-dependent survival in Caenorhabditis elegans
Across organisms, manipulation of biosynthetic capacity arrests development early in life,
but can increase health-and lifespan post-developmentally. Here we demonstrate that this
developmental arrest is not sickness but rather a regulated survival program responding to
reduced cellular performance. We inhibited protein synthesis by reducing ribosome
biogenesis (rps-11/RPS11 RNAi), translation initiation (ifg-1/EIF3G mutation and egl-
45/EIF3A RNAi), or ribosome progression (cycloheximide treatment), all of which result in a …
but can increase health-and lifespan post-developmentally. Here we demonstrate that this
developmental arrest is not sickness but rather a regulated survival program responding to
reduced cellular performance. We inhibited protein synthesis by reducing ribosome
biogenesis (rps-11/RPS11 RNAi), translation initiation (ifg-1/EIF3G mutation and egl-
45/EIF3A RNAi), or ribosome progression (cycloheximide treatment), all of which result in a …
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