Identification of the human chromosomal region containing the iridogoniodysgenesis anomaly locus by genomic-mismatch scanning
F Mirzayans, AJ Mears, SW Guo, WG Pearce… - The American Journal of …, 1997 - Elsevier
Genome-mismatch scanning (GMS) is a new method of linkage analysis that rapidly isolates
regions of identity between two genomes. DNA molecules from regions of identity by
descent from two relatives are isolated based on their ability to form extended mismatch-free
hetero-duplexes. We have applied this rapid technology to identify the chromosomal region
shared by two fifth-degree cousins with autosomal dominant iridogoniodysgenesis anomaly
(IGDA), a rare ocular neurocristopathy. Markers on the short arm of human chromosome 6p …
regions of identity between two genomes. DNA molecules from regions of identity by
descent from two relatives are isolated based on their ability to form extended mismatch-free
hetero-duplexes. We have applied this rapid technology to identify the chromosomal region
shared by two fifth-degree cousins with autosomal dominant iridogoniodysgenesis anomaly
(IGDA), a rare ocular neurocristopathy. Markers on the short arm of human chromosome 6p …
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