Impact of topoisomerase II alpha and spermine on the clinical outcome of children with acute lymphoblastic leukemia
N Grandgirard, B Ly-Sunnaram, D Ferrant… - Leukemia research, 2004 - Elsevier
It has been reported in the literature that a leukemic cell may be (or become) resistant to anti-
cancer treatment because many mechanisms, such as efflux membrane pump (multi-drug
resistance, MDR-P170), intracellular transport (LRP, MRP), or different detoxification
systems (glutathione transferases, methallothioneines) may be implicated. Topoisomerase II
alpha (TopoII) are also reported as responsible for resistance since their main action is to
repair DNA breakage. Polyamines are described as having a protective DNA action by …
cancer treatment because many mechanisms, such as efflux membrane pump (multi-drug
resistance, MDR-P170), intracellular transport (LRP, MRP), or different detoxification
systems (glutathione transferases, methallothioneines) may be implicated. Topoisomerase II
alpha (TopoII) are also reported as responsible for resistance since their main action is to
repair DNA breakage. Polyamines are described as having a protective DNA action by …
