To assess the changes in counterregulatory hormones overnight after an afternoon of
structured exercise or sedentary activity in children with type 1 diabetes mellitus (T1DM), the
Diabetes Research in Children Network (DirecNet) studied 50 children (10 to< 18 yr) with
T1DM in five clinical research centers on two separate days (with and without an afternoon
exercise session) using a crossover design. Glucose, epinephrine, norepinephrine, cortisol,
growth hormone (GH), and glucagon concentrations were measured hourly overnight …