Improvement of aggressive behavior and quality of life impairment following S-adenosyl-methionine (SAM-e) augmentation in schizophrenia
RD Strous, MS Ritsner, S Adler, Y Ratner… - European …, 2009 - Elsevier
S-Adenosyl-Methionine (SAM-e), functions as a primary methyl group donor for several
metabolic compounds. Since SAM-e is involved in several metabolic processes, its
administration may have a role in the amelioration of several disorders. In addition, SAM-e
increases catechol-O-methyltransferase (COMT) enzyme activity, which may ameliorate
aggressive symptoms in certain patients. We have therefore investigated the efficacy of SAM-
e in managing schizophrenia symptomatology in patients with the low activity COMT …
metabolic compounds. Since SAM-e is involved in several metabolic processes, its
administration may have a role in the amelioration of several disorders. In addition, SAM-e
increases catechol-O-methyltransferase (COMT) enzyme activity, which may ameliorate
aggressive symptoms in certain patients. We have therefore investigated the efficacy of SAM-
e in managing schizophrenia symptomatology in patients with the low activity COMT …
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