In vivo drug interactions of itopride and trimethylamine mediated by flavin-containing monooxygenase 3 in humanized-liver mice
M Shimizu, S Uehara, H Suemizu… - Drug Metabolism and …, 2021 - Elsevier
Flavin-containing monooxygenase (FMO) catalyzes the oxygenation of a wide variety of
medicines and dietary-derived compounds. However, little information is available regarding
drug interactions mediated by FMO3 in vivo. Consequently, we investigated interactions
between FMO substrates in humanized-liver mice. Trimethylamine-d 9 and itopride were,
respectively, intravenously and orally administered to humanized-liver mice (n= 5–7). The
pharmacokinetic profiles of itopride (the victim drug) in the presence of trimethylamine (the …
medicines and dietary-derived compounds. However, little information is available regarding
drug interactions mediated by FMO3 in vivo. Consequently, we investigated interactions
between FMO substrates in humanized-liver mice. Trimethylamine-d 9 and itopride were,
respectively, intravenously and orally administered to humanized-liver mice (n= 5–7). The
pharmacokinetic profiles of itopride (the victim drug) in the presence of trimethylamine (the …
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