In vitro formation of lacuna structure by human dermal fibroblasts co-cultured with porcine chondrocytes on a 3D biodegradable scaffold
X Liu, G Zhou, W Liu, W Zhang, L Cui, Y Cao - Biotechnology letters, 2007 - Springer
X Liu, G Zhou, W Liu, W Zhang, L Cui, Y Cao
Biotechnology letters, 2007•SpringerDermal fibroblasts (DF) possess chondrogenic differentiation potential but whether DF, or a
subpopulation of DF, can form a typical cartilage structure in culture is unknown. In this
study, human DF were co-cultured with porcine articular chondrocytes on a biodegradable
scaffold of polylactic acid/polyglycolic acid. Histological analysis demonstrated that some
DFs can be induced to form cartilage lacuna structure showing the existence of a
chondrogenic subpopulation of human DF. Moreover, the 3D-co-culture system can serve as …
subpopulation of DF, can form a typical cartilage structure in culture is unknown. In this
study, human DF were co-cultured with porcine articular chondrocytes on a biodegradable
scaffold of polylactic acid/polyglycolic acid. Histological analysis demonstrated that some
DFs can be induced to form cartilage lacuna structure showing the existence of a
chondrogenic subpopulation of human DF. Moreover, the 3D-co-culture system can serve as …
Abstract
Dermal fibroblasts (DF) possess chondrogenic differentiation potential but whether DF, or a subpopulation of DF, can form a typical cartilage structure in culture is unknown. In this study, human DF were co-cultured with porcine articular chondrocytes on a biodegradable scaffold of polylactic acid/polyglycolic acid. Histological analysis demonstrated that some DFs can be induced to form cartilage lacuna structure showing the existence of a chondrogenic subpopulation of human DF. Moreover, the 3D-co-culture system can serve as an optimal model for directing stem cell differentiation in vitro.
Springer
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