Incidental carcinomas in prophylactic specimens in BRCA1 and BRCA2 germ-line mutation carriers, with emphasis on fallopian tube lesions: report of 6 cases and …
ML Carcangiu, B Peissel, B Pasini… - The American journal …, 2006 - journals.lww.com
The identification of germ-line mutations in 2 genes (BRCA1 and BRCA2) responsible for
the majority of hereditary ovarian cancers has led an increasing number of women carriers
of these mutations to undergo prophylactic oophorectomy (PO) to reduce their risk of
subsequent ovarian carcinoma. A large number of unexpected, clinically occult neoplasms
are thus being discovered. Up to December 2004, the Medical Genetics Service of the
National Cancer Institute in Milan, Italy, has tested 756 probands from breast and/or ovarian …
the majority of hereditary ovarian cancers has led an increasing number of women carriers
of these mutations to undergo prophylactic oophorectomy (PO) to reduce their risk of
subsequent ovarian carcinoma. A large number of unexpected, clinically occult neoplasms
are thus being discovered. Up to December 2004, the Medical Genetics Service of the
National Cancer Institute in Milan, Italy, has tested 756 probands from breast and/or ovarian …
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