Increased levels of NLRP3 in children with febrile seizures

Z Liu, H Xian, X Ye, J Chen, Y Ma, W Huang - Brain and Development, 2020 - Elsevier
Objective Febrile seizures (FS) are the most common convulsions in childhood. Interleukin-
1beta (IL-1β) is proposed to play an important role in the development of FS, from in vitro
data and data from peripheral blood samples. IL-1β secretion is needed for activation of the
NLR family, pyrin-domain containing 3 (NLRP3) inflammasome. However, whether NLRP3
play a role in the development of FS remains unknown. This study aimed to investigate the
role of NLRP3 in FS. Methods Thirty-two FS cases and twenty-two matched controls were …
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