Induction of VEGF gene transcription by IL-1 β is mediated through stress-activated MAP kinases and Sp1 sites in cardiac myocytes
T Tanaka, H Kanai, K Sekiguchi, Y Aihara… - Journal of Molecular and …, 2000 - Elsevier
Interleukin-1 β (IL-1 β) is a multipotent cytokine participating in a variety of cardiovascular
diseases. In this study, we examined the effects of IL-1 β on the expression of vascular
endothelial cell growth factor (VEGF) and pursued the molecular mechanisms underlying
this effect. Treatment of cultured neonatal rat cardiac myocytes with IL-1 β increased the
levels of VEGF mRNA in a time-and a concentration-dependent manner. These effects were
completely abolished by SB203580 and SB202190 (p38 MAPK inhibitors) but not by …
diseases. In this study, we examined the effects of IL-1 β on the expression of vascular
endothelial cell growth factor (VEGF) and pursued the molecular mechanisms underlying
this effect. Treatment of cultured neonatal rat cardiac myocytes with IL-1 β increased the
levels of VEGF mRNA in a time-and a concentration-dependent manner. These effects were
completely abolished by SB203580 and SB202190 (p38 MAPK inhibitors) but not by …
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