Influence of cationic superoxide generation enhancing protein (SGEP) on phagocytic and intracellular bactericidal activity of human polymorphonuclear cells
W Pruzanski, S Saito, M Alam, NS Ranadive - Inflammation, 1988 - Springer
W Pruzanski, S Saito, M Alam, NS Ranadive
Inflammation, 1988•SpringerCationic fraction III from the lysosomes of normal human peripheral blood
polymorphonuclear cells (PMNs) was found to contain superoxide generation enhancing
protein (SGEP). Herein, we report on the influence of partially purified SGEP obtained from
fraction III (subfractions III-5 and III-6), on various phagocytic functions of human PMNs.
SGEP markedly enhanced intracellular bactericidal activity of human peripheral PMNs. The
enhancement was time and dose dependent. It also reduced adhesiveness of the PMNs …
polymorphonuclear cells (PMNs) was found to contain superoxide generation enhancing
protein (SGEP). Herein, we report on the influence of partially purified SGEP obtained from
fraction III (subfractions III-5 and III-6), on various phagocytic functions of human PMNs.
SGEP markedly enhanced intracellular bactericidal activity of human peripheral PMNs. The
enhancement was time and dose dependent. It also reduced adhesiveness of the PMNs …
Abstract
Cationic fraction III from the lysosomes of normal human peripheral blood polymorphonuclear cells (PMNs) was found to contain superoxide generation enhancing protein (SGEP). Herein, we report on the influence of partially purified SGEP obtained from fraction III (subfractions III-5 and III-6), on various phagocytic functions of human PMNs. SGEP markedly enhanced intracellular bactericidal activity of human peripheral PMNs. The enhancement was time and dose dependent. It also reduced adhesiveness of the PMNs. SGEP did not influence chemotaxis, phagocytosis or phagocytic index. These findings are compatible with our original observation regarding superoxide generation enhancement properties of SGEP.
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