Age-related macular degeneration (AMD) is a leading cause of irreversible vision loss
among the elderly population. Vascular endothelial growth factor (VEGF) is essential for
choroidal neovascularization (CNV) development in advanced, wet AMD. Chrysin (5, 7-
dihydroxyflavone) is a natural flavonoid with anti-inflammatory, anti-oxidative, and anti-
angiogenic effects. We hypothesized that intravitreally injected chrysin may inhibit CNV due
to its inhibitory effect on angiogenesis. To determine the effects of chrysin on an …

Purpose: To determine the effects of a single intravitreal injection of chrysin to inhibit
angiogenesis in an experimental rat model of choroidal neovascularization (CNV). Methods:
A diode laser was used to break Bruch's membrane in Brown Norway rats. One week later
after laser photocoagulation, each rat was injected intravitreally with 5 µl of 15 mg/ml chrysin
in the right eye and same amount of solvent solution in the left eye. The formation of CNV
was evaluated according to the size and intensity of dye leakage by fluorescein angiography …