Inhibition of TRIM8 restrains ischaemia-reperfusion-mediated cerebral injury by regulation of NF-κB activation associated inflammation and apoptosis
X Bai, YL Zhang, LN Liu - Experimental Cell Research, 2020 - Elsevier
Stroke is a leading global cause of mortality and disability. However, the pathogenesis that
contributes to stroke has not been fully understood. The tripartite motif (TRIM)-containing
proteins usually exhibit essential regulatory roles during various biological processes.
TRIM8 is a RING domain-containing E3 ubiquitin ligase, playing crucial roles in regulating
inflammation and apoptosis. In the present study, we reported that TRIM8 expression was
significantly induced in the peri-infarct cortex area of mice after stroke onset. TRIM8 siRNA in …
contributes to stroke has not been fully understood. The tripartite motif (TRIM)-containing
proteins usually exhibit essential regulatory roles during various biological processes.
TRIM8 is a RING domain-containing E3 ubiquitin ligase, playing crucial roles in regulating
inflammation and apoptosis. In the present study, we reported that TRIM8 expression was
significantly induced in the peri-infarct cortex area of mice after stroke onset. TRIM8 siRNA in …
以上显示的是最相近的搜索结果。 查看全部搜索结果