Inhibition of caspases but not of calpains temporarily protect against C2-ceramide-induced death of CAD cells
G Arboleda, C Waters, R Gibson - Neuroscience letters, 2007 - Elsevier
Evidence has implicated apoptosis as a mechanism underlying cell death in diverse
neurodegenerative diseases including Parkinson's disease (PD). Endogenous agents such
as TNF-α, INF-γ, IL-1β and others stress signals activate the sphingomyelin pathway
increasing ceramide levels. Ceramide triggers apoptotic pathways while inhibiting survival
signalling, and is involved in the regulation of intracellular Ca2+ homeostasis and
compartmentalisation. The contribution of caspases in neuronal apoptosis has been …
neurodegenerative diseases including Parkinson's disease (PD). Endogenous agents such
as TNF-α, INF-γ, IL-1β and others stress signals activate the sphingomyelin pathway
increasing ceramide levels. Ceramide triggers apoptotic pathways while inhibiting survival
signalling, and is involved in the regulation of intracellular Ca2+ homeostasis and
compartmentalisation. The contribution of caspases in neuronal apoptosis has been …
