Inhibition of eotaxin-mediated human eosinophil activation and migration by the selective cyclic nucleotide phosphodiesterase type 4 inhibitor rolipram
LF Santamaria, JM Palacios, J Beleta - British journal of …, 1997 - ncbi.nlm.nih.gov
LF Santamaria, JM Palacios, J Beleta
British journal of pharmacology, 1997•ncbi.nlm.nih.gov… 30% at a rolipram concentration of 0.1 mM. 4 We conclude that the selective PDE 4
inhibitor rolipram decreases eotaxin mediated eosinophil activation, an observation that
may contribute to elucidate the mechanism by which PDE 4 inhibitors reduce antigen-induced
eosinophil infiltration in different animal models of allergic inflammation. Keywords: Human
eosinophil; eotaxin; PDE 4; phosphodiesterase inhibitor; rolipram …
inhibitor rolipram decreases eotaxin mediated eosinophil activation, an observation that
may contribute to elucidate the mechanism by which PDE 4 inhibitors reduce antigen-induced
eosinophil infiltration in different animal models of allergic inflammation. Keywords: Human
eosinophil; eotaxin; PDE 4; phosphodiesterase inhibitor; rolipram …
Abstract
1. The effect of the selective type 4 phosphodiesterase (PDE 4) inhibitor rolipram on human eosinophil activation and migration mediated by eotaxin was investigated.
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