Inhibition of sodium-dependent L-leucine uptake in rat brain synaptosomes
T Chee-Hong, N Foong-Har - Biochemical Pharmacology, 1990 - Elsevier
Synaptosomes isolated from adult rat cerebral cortices were used for studying the uptake of l-
leucine by the Na+-dependent route. Three non-metabolizable amino acid analogues,
which had been used previously to discriminate the Na+-dependent A-type uptake system of
animal cells, were employed in this study. It was found that Na+-dependent uptake of
leucine was insensitive to inhibition by 2-aminoisobutyric acid (AIB) and N-
methylaminoisobutyric acid (MeAIB) whereas N-methylalanine (NMA) was markedly …
leucine by the Na+-dependent route. Three non-metabolizable amino acid analogues,
which had been used previously to discriminate the Na+-dependent A-type uptake system of
animal cells, were employed in this study. It was found that Na+-dependent uptake of
leucine was insensitive to inhibition by 2-aminoisobutyric acid (AIB) and N-
methylaminoisobutyric acid (MeAIB) whereas N-methylalanine (NMA) was markedly …
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