Intensity correction method customized for multi-animal abdominal MR imaging with 3T clinical scanner and multi-array coil
M Mitsuda, M Yamaguchi, R Nakagami… - … Resonance in Medical …, 2013 - jstage.jst.go.jp
M Mitsuda, M Yamaguchi, R Nakagami, T Furuta, N Sekine, M Niitsu, N Moriyama, H Fujii
Magnetic Resonance in Medical Sciences, 2013•jstage.jst.go.jpPurpose: Simultaneous magnetic resonance (MR) imaging of multiple small animals in a
single session increases throughput of preclinical imaging experiments. Such imaging using
a 3-tesla clinical scanner with multi-array coil requires correction of intensity variation
caused by the inhomogeneous sensitivity profile of the coil. We explored a method for
correcting intensity that we customized for multi-animal MR imaging, especially abdominal
imaging. Method: Our institutional committee for animal experimentation approved the …
single session increases throughput of preclinical imaging experiments. Such imaging using
a 3-tesla clinical scanner with multi-array coil requires correction of intensity variation
caused by the inhomogeneous sensitivity profile of the coil. We explored a method for
correcting intensity that we customized for multi-animal MR imaging, especially abdominal
imaging. Method: Our institutional committee for animal experimentation approved the …
抄録
Purpose: Simultaneous magnetic resonance (MR) imaging of multiple small animals in a single session increases throughput of preclinical imaging experiments. Such imaging using a 3-tesla clinical scanner with multi-array coil requires correction of intensity variation caused by the inhomogeneous sensitivity profile of the coil. We explored a method for correcting intensity that we customized for multi-animal MR imaging, especially abdominal imaging.
Method: Our institutional committee for animal experimentation approved the protocol. We acquired high resolution T 1-, T 2-, and T 2*-weighted images and low resolution proton density-weighted images (PDWIs) of 4 rat abdomens simultaneously using a 3T clinical scanner and custom-made multi-array coil. For comparison, we also acquired T 1-, T 2-, and T 2*-weighted volume coil images in the same rats in 4 separate sessions. We used software created in-house to correct intensity variation. We applied thresholding to the PDWIs to produce binary images that displayed only a signal-producing area, calculated multi-array coil sensitivity maps by dividing low-pass filtered PDWIs by low-pass filtered binary images pixel by pixel, and divided uncorrected T 1-, T 2-, or T 2*-weighted images by those maps to obtain intensity-corrected images. We compared tissue contrast among the liver, spinal canal, and muscle between intensity-corrected multi-array coil images and volume coil images.
Results: Our intensity correction method performed well for all pulse sequences studied and corrected variation in original multi-array coil images without deteriorating the throughput of animal experiments. Tissue contrasts were comparable between intensity-corrected multi-array coil images and volume coil images.
Conclusion: Our intensity correction method customized for multi-animal abdominal MR imaging using a 3T clinical scanner and dedicated multi-array coil could facilitate image interpretation.
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