Intermolecular interaction of voriconazole analogues with model membrane by DSC and NMR, and their antifungal activity using NMR based metabolic profiling
V Kalamkar, M Joshi, V Borkar, S Srivastava… - Bioorganic & medicinal …, 2013 - Elsevier
The development of novel antifungal agents with high susceptibility and increased potency
can be achieved by increasing their overall lipophilicity. To enhance the lipophilicity of
voriconazole, a second generation azole antifungal agent, we have synthesized its
carboxylic acid ester analogues, namely p-methoxybenzoate (Vpmb), toluate (Vtol),
benzoate (Vbz) and p-nitrobenzoate (Vpnb). The intermolecular interactions of these
analogues with model membrane have been investigated using nuclear magnetic …
can be achieved by increasing their overall lipophilicity. To enhance the lipophilicity of
voriconazole, a second generation azole antifungal agent, we have synthesized its
carboxylic acid ester analogues, namely p-methoxybenzoate (Vpmb), toluate (Vtol),
benzoate (Vbz) and p-nitrobenzoate (Vpnb). The intermolecular interactions of these
analogues with model membrane have been investigated using nuclear magnetic …
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