Investigation and threshold of optimum blood concentration of voriconazole: a descriptive statistical meta-analysis
Y Hamada, Y Seto, K Yago, M Kuroyama - Journal of Infection and …, 2012 - Elsevier
Voriconazole (VRCZ) reportedly possesses a broad spectrum of antifungal activity against
Aspergillus spp. and Candida spp., and the blood concentration of VRCZ is correlated with
both the efficacy and the adverse effects of this drug. Monitoring of the blood concentration
target level of VRCZ has not yet been widely adopted in the medical field, and no evidence
concerning this target level has been reported. Accordingly, we used a meta-analysis to
investigate the optimal blood concentration of VRCZ. Using data from 12 reports, we found …
Aspergillus spp. and Candida spp., and the blood concentration of VRCZ is correlated with
both the efficacy and the adverse effects of this drug. Monitoring of the blood concentration
target level of VRCZ has not yet been widely adopted in the medical field, and no evidence
concerning this target level has been reported. Accordingly, we used a meta-analysis to
investigate the optimal blood concentration of VRCZ. Using data from 12 reports, we found …
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