[HTML][HTML] JTE-607, a multiple cytokine production inhibitor, ameliorates disease in a SCID mouse xenograft acute myeloid leukemia model
N Uesato, K Fukui, J Maruhashi, A Tojo… - Experimental hematology, 2006 - Elsevier
OBJECTIVE: Accumulating findings suggest that in acute myeloid leukemia (AML) patients,
proinflammatory cytokines and growth factors play important roles in the proliferation and
survival of AML cells in an autocrine and paracrine manner, leading to deterioration of AML.
JTE-607 is a multiple cytokine inhibitor that potently suppresses production of
proinflammatory cytokines. In the present study, we investigated the potency of JTE-607 as
an antileukemic agent by exploiting a SCID mouse acute leukemia model. METHODS: SCID …
proinflammatory cytokines and growth factors play important roles in the proliferation and
survival of AML cells in an autocrine and paracrine manner, leading to deterioration of AML.
JTE-607 is a multiple cytokine inhibitor that potently suppresses production of
proinflammatory cytokines. In the present study, we investigated the potency of JTE-607 as
an antileukemic agent by exploiting a SCID mouse acute leukemia model. METHODS: SCID …
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