Mu-opioid agonists and N-methyl-d-aspartate (NMDA) receptor antagonists have been
shown to attenuate mechanical allodynia in neuropathic pain models. We have previously
reported that 2Hz electroacupuncture (EA) produced analgesia via releasing endogenous
opioid peptides (ie β-endorphin and endomorphin) and the activated μ-opioid receptors. The
present study aimed to examine whether ketamine, an NMDA receptor antagonist, can
enhance the anti-allodynic effects induced by 2Hz EA in a rat model of neuropathic pain …