Kidney hypoxia, attributable to increased oxygen consumption, induces nephropathy independently of hyperglycemia and oxidative stress

M Friederich-Persson, E Thörn, P Hansell… - …, 2013 - Am Heart Assoc
Diabetic nephropathy is strongly associated with both increased oxidative stress and kidney
tissue hypoxia. The increased oxidative stress causes increased kidney oxygen
consumption resulting in kidney tissue hypoxia. To date, it has been difficult to determine the
role of kidney hypoxia, per se, for the development of nephropathy. We tested the hypothesis
that kidney hypoxia, without confounding factors such as hyperglycemia or elevated
oxidative stress, results in nephropathy. To induce kidney hypoxia, dinitrophenol (30 mg per …

[HTML][HTML] KIDNEY HYPOXIA, DUE TO INCREASED OXYGEN CONSUMPTION, INDUCES NEPHROPATHY INDEPENDENTLY OF HYPERGLYCEMIA AND OXIDATIVE …

M Friederich-Persson, E Thörn, P Hansell… - …, 2013 - ncbi.nlm.nih.gov
Diabetic nephropathy is strongly associated with both increased oxidative stress and kidney
tissue hypoxia. The increased oxidative stress causes increased kidney oxygen
consumption resulting in kidney tissue hypoxia. It has so far been difficult to determine the
role of kidney hypoxia per se for the development of nephropathy. We tested the hypothesis
that kidney hypoxia, without confounding factors such as hyperglycemia or elevated
oxidative stress, results in nephropathy.
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