Laboratory studies of the impact of calcite on in vitro and in vivo effects of coal dust: A potential preventive agent for coal workers' pneumoconiosis?
American journal of industrial medicine, 2013•Wiley Online Library
Background Bioavailable iron (BAI) in coal, which may play a key role in causing coal
workers' pneumoconiosis (CWP), is present at relatively high levels in Appalachian coals.
Calcite decreases BAI and is more plentiful in Western coals than in Appalachian coals,
possibly explaining the lower CWP prevalence among Western miners. Methods We
measured effects of calcite on BAI in non‐cellular and cellular systems involving
Pennsylvania (PA) coal dust. We also tested in vivo effects of calcite on transferrin receptor …
workers' pneumoconiosis (CWP), is present at relatively high levels in Appalachian coals.
Calcite decreases BAI and is more plentiful in Western coals than in Appalachian coals,
possibly explaining the lower CWP prevalence among Western miners. Methods We
measured effects of calcite on BAI in non‐cellular and cellular systems involving
Pennsylvania (PA) coal dust. We also tested in vivo effects of calcite on transferrin receptor …
Background
Bioavailable iron (BAI) in coal, which may play a key role in causing coal workers' pneumoconiosis (CWP), is present at relatively high levels in Appalachian coals. Calcite decreases BAI and is more plentiful in Western coals than in Appalachian coals, possibly explaining the lower CWP prevalence among Western miners.
Methods
We measured effects of calcite on BAI in non‐cellular and cellular systems involving Pennsylvania (PA) coal dust. We also tested in vivo effects of calcite on transferrin receptor and markers of epithelial mesenchymal transition (EMT) and inflammation in mice exposed to PA coal.
Results
Calcite rapidly eliminated BAI in an aqueous suspension of PA coal. Ferritin induction in human lung epithelial cells exposed to PA coal was effectively eliminated by calcite. Mouse lung tissue markers indicated increased EMT after exposure to PA coal dust, but not after exposure to PA coal plus calcite. Markers of inflammation increased following exposure to PA coal alone, but not following exposure to PA coal plus calcite.
Conclusion
Additional research may lead to the use of supplemental calcite in coal mining as a safe and effective way to prevent CWP among Appalachian coal miners. Am. J. Ind. Med. 56:292–299, 2013. © 2012 Wiley Periodicals, Inc.
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