Lipopolysaccharide analogs improve efficacy of acellular pertussis vaccine and reduce type I hypersensitivity in mice
J Geurtsen, HA Banus, ER Gremmer… - Clinical and Vaccine …, 2007 - Am Soc Microbiol
Pertussis is an infectious disease of the respiratory tract that is caused by the gram-negative
bacterium Bordetella pertussis. Although acellular pertussis (aP) vaccines are safe, they are
not fully effective and thus require improvement. In contrast to whole-cell pertussis (wP)
vaccines, aP vaccines do not contain lipopolysaccharide (LPS). Monophosphoryl lipid A
(MPL) and Neisseria meningitidis LpxL2 LPS have been shown to display immune-
stimulating activity while exerting little endotoxin activity. Therefore, we evaluated whether …
bacterium Bordetella pertussis. Although acellular pertussis (aP) vaccines are safe, they are
not fully effective and thus require improvement. In contrast to whole-cell pertussis (wP)
vaccines, aP vaccines do not contain lipopolysaccharide (LPS). Monophosphoryl lipid A
(MPL) and Neisseria meningitidis LpxL2 LPS have been shown to display immune-
stimulating activity while exerting little endotoxin activity. Therefore, we evaluated whether …
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