[HTML][HTML] Long Non-coding RNA LINC00114 Facilitates Colorectal Cancer Development Through EZH2/DNMT1-Induced miR-133b Suppression
L Lv, L He, S Chen, Y Yu, G Che, X Tao, S Wang… - Frontiers in …, 2019 - frontiersin.org
This study aimed to identify the roles of the long non-coding RNA LINC00114 in colorectal
cancer (CRC) development. The expression levels of LINC00114 and miR-133b in CRC
were determined by reverse transcription (RT)-polymerase chain reaction (PCR) and the
functions of LINC00114 in CRC were evaluated in vitro and in vivo. Methylation-specific
PCR assay was performed to detect the miR-133b promoter methylation in CRC cells.
Bioinformatics analysis, RNA immunoprecipitation, dual luciferase assay, RNA pull-down, co …
cancer (CRC) development. The expression levels of LINC00114 and miR-133b in CRC
were determined by reverse transcription (RT)-polymerase chain reaction (PCR) and the
functions of LINC00114 in CRC were evaluated in vitro and in vivo. Methylation-specific
PCR assay was performed to detect the miR-133b promoter methylation in CRC cells.
Bioinformatics analysis, RNA immunoprecipitation, dual luciferase assay, RNA pull-down, co …
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