MHC bias of Mls-1 recognition is not influenced by thymic positive selection
P Nguyen, DL Woodland, MA Blackman - Cellular immunology, 1996 - Elsevier
In contrast to T cell recognition of conventional peptide/MHC, T cell recognition of
superantigen is not MHC-restricted. However, an influence of MHC polymorphism on
specificity is consistent with accumulating data suggesting a TCR/MHC interaction during T
cell recognition of superantigen. We have previously shown that T cells from Vβ8. 1 β-chain
transgenic mice show an unexpected bias against recognition of Mls-1 presented by H-
2dspleen cells. In the current studies we have examined whether thymic positive selection in …
superantigen is not MHC-restricted. However, an influence of MHC polymorphism on
specificity is consistent with accumulating data suggesting a TCR/MHC interaction during T
cell recognition of superantigen. We have previously shown that T cells from Vβ8. 1 β-chain
transgenic mice show an unexpected bias against recognition of Mls-1 presented by H-
2dspleen cells. In the current studies we have examined whether thymic positive selection in …
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