MK-801-induced and scopolamine-induced hyperactivity in rats neonatally treated chronically with MK-801
H Furuie, K Yamada, Y Ichitani - Behavioural Pharmacology, 2013 - journals.lww.com
This study investigated the effects of chronic neonatal blockade of N-methyl-D-aspartate
(NMDA) receptors on NMDA and muscarinic acetylcholine receptor-mediated
neurotransmission in adulthood. Rats neonatally treated chronically with MK-801/saline
were tested for 40 min, at the age of 14–16 weeks, for locomotor activity in an open field
immediately after acute administration of MK-801 (0.2 mg/kg) or scopolamine (0.4–2.0
mg/kg). Rats neonatally treated with MK-801 showed significantly higher locomotor activity …
(NMDA) receptors on NMDA and muscarinic acetylcholine receptor-mediated
neurotransmission in adulthood. Rats neonatally treated chronically with MK-801/saline
were tested for 40 min, at the age of 14–16 weeks, for locomotor activity in an open field
immediately after acute administration of MK-801 (0.2 mg/kg) or scopolamine (0.4–2.0
mg/kg). Rats neonatally treated with MK-801 showed significantly higher locomotor activity …
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