Management of segmental bony defects: the role of osteoconductive orthobiologics
MD McKee - JAAOS-Journal of the American Academy of …, 2006 - journals.lww.com
JAAOS-Journal of the American Academy of Orthopaedic Surgeons, 2006•journals.lww.com
Our knowledge about, and the availability of, orthobiologic materials has increased
exponentially in the last decade. Although previously confined to the experimental or animal‐
model realm, several orthobiologics have been shown to be useful in a variety of clinical
situations. As surgical techniques in vascular anastomosis, softtissue coverage, limb
salvage, and fracture stabilization have improved, the size and frequency of bony defects
(commensurate with the severity of the initial injury) have increased, as well. Because all …
exponentially in the last decade. Although previously confined to the experimental or animal‐
model realm, several orthobiologics have been shown to be useful in a variety of clinical
situations. As surgical techniques in vascular anastomosis, softtissue coverage, limb
salvage, and fracture stabilization have improved, the size and frequency of bony defects
(commensurate with the severity of the initial injury) have increased, as well. Because all …
Abstract
Our knowledge about, and the availability of, orthobiologic materials has increased exponentially in the last decade. Although previously confined to the experimental or animal‐model realm, several orthobiologics have been shown to be useful in a variety of clinical situations. As surgical techniques in vascular anastomosis, softtissue coverage, limb salvage, and fracture stabilization have improved, the size and frequency of bony defects (commensurate with the severity of the initial injury) have increased, as well. Because all methods of managing segmental bony defects have drawbacks, a need remains for a readily available, void‐filling, inexpensive bone substitute. Such a bone substitute fulfills a permissive role in allowing new bone to grow into a given defect. Such potential osteoconductive materials include ceramics, calcium sulfate or calcium phosphate compounds, hydroxyapatite, deproteinized bone, corals, and recently developed polymers. Some materials that have osteoinductive properties, such as demineralized bone matrix, also display prominent osteoconductive properties.
Lippincott Williams & Wilkins
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