Maternal SSRI discontinuation, use, psychiatric disorder and the risk of autism in children: a meta‐analysis of cohort studies

YC Kaplan, E Keskin‐Arslan, S Acar… - British journal of …, 2017 - Wiley Online Library
YC Kaplan, E Keskin‐Arslan, S Acar, K Sozmen
British journal of clinical pharmacology, 2017Wiley Online Library
We undertook an exclusive meta‐analysis of cohort studies investigating the possible link
between prenatal selective serotonin reuptake inhibitor (SSRI) exposure and autism
spectrum disorders (ASD) in children to further investigate our previous suggestion of
confounding by indication. The point estimates regarding the following cohorts were
extracted and pooled:(1) pregnant women who discontinued SSRI until 3 months before
pregnancy;(2) pregnant women who were exposed to SSRI during pregnancy; and (3) …
We undertook an exclusive meta‐analysis of cohort studies investigating the possible link between prenatal selective serotonin reuptake inhibitor (SSRI) exposure and autism spectrum disorders (ASD) in children to further investigate our previous suggestion of confounding by indication. The point estimates regarding the following cohorts were extracted and pooled: (1) pregnant women who discontinued SSRI until 3 months before pregnancy; (2) pregnant women who were exposed to SSRI during pregnancy; and (3) pregnant women with maternal psychiatric disorder but no exposure to SSRI during pregnancy. Although the pooled point estimate of the first cohort showed a trend for increase, it did not reach significance. The pooled point estimates of the latter cohorts showed a significant association with ASD which strengthens our previous suggestion of confounding by indication. Future studies should be adequately designed to differentiate whether the previously suggested association is a result of maternal psychiatric disorder or SSRI exposure or both.
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