[HTML][HTML] Mechanical stress induces the expression of high molecular mass heat shock protein in human chondrocytic cell line CS-OKB

T Chano, M Tanaka, S Hukuda, Y Saeki - Osteoarthritis and cartilage, 2000 - Elsevier
Objective Mechanical stress is an important regulator of chondrocyte function, but it is
unknown how chondrocytes respond to mechanical stress. This study was performed to
clarify the underlying mechanisms in human chondrocytes. Design Using a Flexercell strain
unit (25% maximal elongation, 0.05 Hz-cyclic manner, and 48h), mechanical stimulation was
applied to confluent CS-OKB cells, human chondrocytic cells. To analyze transcriptional
changes in response to mechanical stress, differential display reverse transcription …
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