Medial fetal ventral mesencephalon: a preferred source for dopamine neuron grafts
LC Costantini, L Lin, O Isacson - Neuroreport, 1997 - journals.lww.com
CURRENTLY, fetal tissue transplantation into patients with Parkinson's disease utilizes the
entire ventral mesencephalon (VM) as donor tissue. However, the resulting mixture of cell
types contains a relatively low proportion of therapeutically relevant dopamine (DA)
neurons. We show that differential dissection of a medial region of embryonic day 14 rat VM
yields a significantly higher proportion of DA neurons (8–10%) than is found in lateral VM
(2%) or whole VM (4–5%). Medial VM also contained a larger number of the specific …
entire ventral mesencephalon (VM) as donor tissue. However, the resulting mixture of cell
types contains a relatively low proportion of therapeutically relevant dopamine (DA)
neurons. We show that differential dissection of a medial region of embryonic day 14 rat VM
yields a significantly higher proportion of DA neurons (8–10%) than is found in lateral VM
(2%) or whole VM (4–5%). Medial VM also contained a larger number of the specific …
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