Mediation of serotonin-induced analgesia by the 5HT2 receptor in the pentobarbital anesthetized mouse model
WA Banks, AJ Kastin, TL Trentman, HS Haynes… - Brain research …, 1988 - Elsevier
Serotonin can induce analgesia when injected directly into the brain, but analgesia after
peripheral administration has been more difficult to show. The pentobarbital anesthetized
mouse (PAM) model, developed to alleviate some of the problems involved in the
measurement of tail flick latency, was used to assess the action of peripherally administered
serotonin. Mice were anesthetized with about 65 mg/kg of sodium pentobarbital IP and their
tail flick latencies measured while they were in stage III anesthesia. In these anesthetized …
peripheral administration has been more difficult to show. The pentobarbital anesthetized
mouse (PAM) model, developed to alleviate some of the problems involved in the
measurement of tail flick latency, was used to assess the action of peripherally administered
serotonin. Mice were anesthetized with about 65 mg/kg of sodium pentobarbital IP and their
tail flick latencies measured while they were in stage III anesthesia. In these anesthetized …
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