Metastatic ovarian carcinoma‐associated subepidermal blistering disease with autoantibodies to both the p200 dermal antigen and the γ2 subunit of laminin 5 …
J Mitsuya, H Hara, K Ito, N Ishii… - British Journal of …, 2008 - academic.oup.com
J Mitsuya, H Hara, K Ito, N Ishii, T Hashimoto, T Terui
British Journal of Dermatology, 2008•academic.oup.comAnti‐p200 pemphigoid is an autoimmune subepidermal blistering disease characterized by
autoantibodies to an unknown 200‐kDa acidic noncollagenous glycoprotein of the lower
lamina lucida, whereas antilaminin 5 mucous membrane pemphigoid is characterized by
autoantibodies to a major basement membrane extracellular matrix, laminin 5. We report a
64‐year‐old Japanese woman with a subepidermal blistering disease associated with
lymph node metastasis of ovarian clear cell carcinoma 10 years after its surgical treatment …
autoantibodies to an unknown 200‐kDa acidic noncollagenous glycoprotein of the lower
lamina lucida, whereas antilaminin 5 mucous membrane pemphigoid is characterized by
autoantibodies to a major basement membrane extracellular matrix, laminin 5. We report a
64‐year‐old Japanese woman with a subepidermal blistering disease associated with
lymph node metastasis of ovarian clear cell carcinoma 10 years after its surgical treatment …
Summary
Anti‐p200 pemphigoid is an autoimmune subepidermal blistering disease characterized by autoantibodies to an unknown 200‐kDa acidic noncollagenous glycoprotein of the lower lamina lucida, whereas antilaminin 5 mucous membrane pemphigoid is characterized by autoantibodies to a major basement membrane extracellular matrix, laminin 5. We report a 64‐year‐old Japanese woman with a subepidermal blistering disease associated with lymph node metastasis of ovarian clear cell carcinoma 10 years after its surgical treatment. Clinical features showed severe blisters and erosions on multiple mucous membranes (i.e. lip, oral cavity, nose, eye, genitalia and anus) and on both the periungual and subungual regions. This is the first report in which an immunoblot analysis revealed the unusual combination of autoantibodies to both the p200 antigen and the γ2 subunit of laminin 5.
Oxford University Press
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