Methazolamide plus aminophylline abrogates hypoxia-mediated endurance exercise impairment

RL Scalzo, SE Binns, AL Klochak… - … Altitude Medicine & …, 2015 - liebertpub.com
RL Scalzo, SE Binns, AL Klochak, GR Giordano, HLR Paris, KJ Sevits, JW Beals, LM Biela
High Altitude Medicine & Biology, 2015liebertpub.com
Abstract Scalzo, Rebecca L., Scott E. Binns, Anna L. Klochak, Gregory R. Giordano, Hunter
LR Paris, Kyle J. Sevits, Joseph W. Beals, Laurie M. Biela, Dennis G. Larson, Gary J.
Luckasen, David Irwin, Thies Schroeder, Karyn L. Hamilton, and Christopher Bell.
Methazolamide plus aminophylline abrogates hypoxia-mediated endurance exercise
impairment. High Alt Med Biol 16: 331–342, 2015.—In hypoxia, endurance exercise
performance is diminished; pharmacotherapy may abrogate this performance deficit. Based …
Abstract
Scalzo, Rebecca L., Scott E. Binns, Anna L. Klochak, Gregory R. Giordano, Hunter L.R. Paris, Kyle J. Sevits, Joseph W. Beals, Laurie M. Biela, Dennis G. Larson, Gary J. Luckasen, David Irwin, Thies Schroeder, Karyn L. Hamilton, and Christopher Bell. Methazolamide plus aminophylline abrogates hypoxia-mediated endurance exercise impairment. High Alt Med Biol 16:331–342, 2015.—In hypoxia, endurance exercise performance is diminished; pharmacotherapy may abrogate this performance deficit. Based on positive outcomes in preclinical trials, we hypothesized that oral administration of methazolamide, a carbonic anhydrase inhibitor, aminophylline, a nonselective adenosine receptor antagonist and phosphodiesterase inhibitor, and/or methazolamide combined with aminophylline would attenuate hypoxia-mediated decrements in endurance exercise performance in humans. Fifteen healthy males (26 ± 5 years, body–mass index: 24.9 ± 1.6 kg/m2; mean ± SD) were randomly assigned to one of four treatments: placebo (n = 9), methazolamide (250 mg; n = 10), aminophylline (400 mg; n = 9), or methazolamide (250 mg) with aminophylline (400 mg; n = 8). On two separate occasions, the first in normoxia (FIO2 = 0.21) and the second in hypoxia (FIO2 = 0.15), participants sat for 4.5 hours before completing a standardized exercise bout (30 minutes, stationary cycling, 100 W), followed by a 12.5-km time trial. The magnitude of time trial performance decrement in hypoxia versus normoxia did not differ between placebo (+3.0 ± 2.7 minutes), methazolamide (+1.4 ± 1.7 minutes), and aminophylline (+1.8 ± 1.2 minutes), all with p > 0.09; however, the performance decrement in hypoxia versus normoxia with methazolamide combined with aminophylline was less than placebo (+0.6 ± 1.5 minutes; p = 0.01). This improvement may have been partially mediated by increased SpO2 in hypoxia with methazolamide combined with aminophylline compared with placebo (73% ± 3% vs. 79% ± 6%; p < 0.02). In conclusion, coadministration of methazolamide and aminophylline may promote endurance exercise performance during a sojourn at high altitude.
Mary Ann Liebert
以上显示的是最相近的搜索结果。 查看全部搜索结果