The anticancer agent 2-cyano-3, 12-dioxooleana-1, 9-dien-28-oic acid (CDDO) and its
methyl ester (CDDO-Me) typically induce a broad spectrum of growth-inhibitory,
proapoptotic, and antiangiogenic responses. Treatment of Panc1, Panc28, and L3. 6pL
pancreatic cancer cells with low micromolar concentrations of CDDO or CDDO-Me resulted
in growth inhibition, induction of apoptosis, and down-regulation of cyclin D1, survivin,
vascular endothelial growth factor (VEGF), and its receptor (VEGFR2). RNA interference …

Methyl 2-cyano-3,12-dioxooleana-1, 9-dien-28-oate decreases specificity protein
transcription factors and inhibits pancreatic tumor growth: Role of microRNA-27a (Molecular
Pharmacology (2010) 78, (226-236)) — MD Anderson Cancer Center … MD Anderson
Cancer Center Home MD Anderson Cancer Center Logo … Methyl 2-cyano-3,12-dioxooleana-1,
9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic
tumor growth: Role of microRNA-27a (Molecular Pharmacology (2010) 78, (226-236)) …