[HTML][HTML] MiR-146a rs2910164 G/C polymorphism and gastric cancer susceptibility: a meta-analysis

Z Xu, L Zhang, H Cao, B Bai - BMC Medical Genetics, 2014 - Springer
Z Xu, L Zhang, H Cao, B Bai
BMC Medical Genetics, 2014Springer
Background Evidence has shown that single nucleotide polymorphism located in pre-
miRNA or mature microRNA may modify various biological processes and affect the
processing of carcinogenesis. Published results about the association between miR-146a
rs2910164 G/C polymorphism and human gastric cancer susceptibility are inconclusive. The
aim of this study was to acquire a more precise effect of the association between the miR-
146a rs2910164 polymorphism and gastric risk by meta-analysis. Methods Eligible genetic …
Background
Evidence has shown that single nucleotide polymorphism located in pre-miRNA or mature microRNA may modify various biological processes and affect the processing of carcinogenesis. Published results about the association between miR-146a rs2910164 G/C polymorphism and human gastric cancer susceptibility are inconclusive. The aim of this study was to acquire a more precise effect of the association between the miR-146a rs2910164 polymorphism and gastric risk by meta-analysis.
Methods
Eligible genetic association studies were searched from PubMed, Web of Knowledge and Chinese Biomedicine Database on human subject. Quantitative data synthesis was conducted for the associations of miR-146a rs2910164 G/C polymorphism with susceptibility to gastric cancer.
Results
Nine eligible studies that included a total of 3,885 gastric cancer patients and 5,396 controls were identified in the present meta-analysis. The overall OR indicated a potential association between rs2910164 polymorphism and GC but the effect was not statistically significant (GG vs. CG/CC: OR = 1.076, 95% CI 0.925-1.251, P = 0.342). When stratifying for population, the result showed that miR-146a rs2910164 GG genotype was associated with increased gastric cancer risk among Chinese in recessive model (GG vs. CG/CC: OR = 1.171, 95% CI 1.050-1.306, P = 0.005). Besides, no significant difference was found in gender, smoking, location, metastasis of lymph node and Laurèn’s classification.
Conclusions
The present meta-analysis suggests an increased risk between miR-146a rs2910164 GG genotype and gastric cancer susceptibility in Chinese based on published literatures.
Springer
以上显示的是最相近的搜索结果。 查看全部搜索结果