MiR-146a rs2910164 G > C polymorphism modulates Notch-1/IL-6 signaling during infection: a possible risk factor for Crohn's disease
Background MiR-146a, an effector mediator, targets Notch-1 and regulates the innate and
adaptive immune systems response. Recently, we reported that Notch-1 signaling plays a
key role in macrophage polarization and response during infection. We employed
Mycobacterium avium paratuberculosis (MAP) infection in Crohn's disease (CD) as a model
to demonstrate the role of Notch-1/IL-6 signaling on MCL-1 based apoptosis and
intracellular MAP infection and persistence. This study was designed to investigate the …
adaptive immune systems response. Recently, we reported that Notch-1 signaling plays a
key role in macrophage polarization and response during infection. We employed
Mycobacterium avium paratuberculosis (MAP) infection in Crohn's disease (CD) as a model
to demonstrate the role of Notch-1/IL-6 signaling on MCL-1 based apoptosis and
intracellular MAP infection and persistence. This study was designed to investigate the …
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