… Also, the severity of renal inflammation in our model which employs healthy rats is probably
less than that seen in older patients with co-morbidities. Nevertheless, our analysis indicates
that our approach allowed us to identify the main changes in gene expression induced by CPB
that are the initiators of local inflammatory response in the kidney. The induction of an acute
phase response in the kidney sets the stage for massive influx of leucocytes (neutrophils,
monocytes/macrophages and lymphocytes), and activation of coagulation cascades. …

Background: Cardiopulmonary bypass (CPB) is a commonly used technique in cardiac
surgery. However, CPB is associated with acute renal dysfunction. Also, a temporary peri-
operative decrease of renal function negatively influences long-term survival. To obtain an
insight into the pathogenesis of renal dysfunction following CPB, we performed a microarray
analysis of kidney gene expression in rat. Methods: Rats underwent CPB or Sham
procedure and were sacrificed at 60 min, 1 and 5 days following the procedure. Microarray …