Model-based optimisation and control strategy for the primary drying phase of a lyophilisation process
B Vanbillemont, N Nicolaï, L Leys, T De Beer - Pharmaceutics, 2020 - mdpi.com
The standard operation of a batch freeze-dryer is protocol driven. All freeze-drying phases
(ie, freezing, primary and secondary drying) are programmed sequentially at fixed time
points and within each phase critical process parameters (CPPs) are typically kept constant
or linearly interpolated between two setpoints. This way of operating batch freeze-dryers is
shown to be time consuming and inefficient. A model-based optimisation and real-time
control strategy that includes model output uncertainty could help in accelerating the primary …
(ie, freezing, primary and secondary drying) are programmed sequentially at fixed time
points and within each phase critical process parameters (CPPs) are typically kept constant
or linearly interpolated between two setpoints. This way of operating batch freeze-dryers is
shown to be time consuming and inefficient. A model-based optimisation and real-time
control strategy that includes model output uncertainty could help in accelerating the primary …
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