Modulation of COX-2 expression by statins in human aortic smooth muscle cells: involvement of geranylgeranylated proteins
F Degraeve, M Bolla, S Blaie, C Créminon… - Journal of Biological …, 2001 - ASBMB
Cyclooxygenase (COX)-2 and COX-1 play an important role in prostacyclin production in
vessels and participate in maintaining vascular homeostasis. Statins are inhibitors of 3-
hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, which is crucial in cholesterol
biosynthesis. Recently, cholesterol-independent effects of statins have been described. In
this study, we evaluated the effect of two inhibitors of HMG CoA reductase, mevastatin and
lovastatin, on the production of prostacyclin and the expression of COX in human aortic …
vessels and participate in maintaining vascular homeostasis. Statins are inhibitors of 3-
hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, which is crucial in cholesterol
biosynthesis. Recently, cholesterol-independent effects of statins have been described. In
this study, we evaluated the effect of two inhibitors of HMG CoA reductase, mevastatin and
lovastatin, on the production of prostacyclin and the expression of COX in human aortic …
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