Modulation of STAT3 Signaling, cell redox defenses and cell cycle checkpoints by β-caryophyllene in cholangiocarcinoma cells: Possible mechanisms accounting for …
Cholangiocarcinoma (CCA) is an aggressive group of biliary tract cancers, characterized by
late diagnosis, low effective chemotherapies, multidrug resistance, and poor outcomes. In
the attempt to identify new therapeutic strategies for CCA, we studied the antiproliferative
activity of a combination between doxorubicin and the natural sesquiterpene β-
caryophyllene in cholangiocarcinoma Mz-ChA-1 cells and nonmalignant H69
cholangiocytes, under both long-term and metronomic schedules. The modulation of STAT3 …
late diagnosis, low effective chemotherapies, multidrug resistance, and poor outcomes. In
the attempt to identify new therapeutic strategies for CCA, we studied the antiproliferative
activity of a combination between doxorubicin and the natural sesquiterpene β-
caryophyllene in cholangiocarcinoma Mz-ChA-1 cells and nonmalignant H69
cholangiocytes, under both long-term and metronomic schedules. The modulation of STAT3 …
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