Molecular cloning of rabbit hyaluronic acid synthases and their expression patterns in synovial membrane and articular cartilage
S Ohno, K Tanimoto, K Fujimoto, C Ijuin… - … et Biophysica Acta (BBA …, 2001 - Elsevier
cDNAs for hyaluronic acid synthases (HAS2 and HAS3) were cloned from a cDNA library of
cultured rabbit synovial membrane cells. The cDNA encoding the open reading frame of
rabbit HAS2 and HAS3 was 1659 nucleotides in length with a predicted molecular mass of
about 63 kDa. The amino acid sequence showed that the rabbit HAS2 was 98.7 and 98.4%,
and HAS3 was 98.2 and 97.5% identical with human and mouse forms of the proteins,
respectively. The predicted sequences for hyaluronic acid (HA) binding motifs and the …
cultured rabbit synovial membrane cells. The cDNA encoding the open reading frame of
rabbit HAS2 and HAS3 was 1659 nucleotides in length with a predicted molecular mass of
about 63 kDa. The amino acid sequence showed that the rabbit HAS2 was 98.7 and 98.4%,
and HAS3 was 98.2 and 97.5% identical with human and mouse forms of the proteins,
respectively. The predicted sequences for hyaluronic acid (HA) binding motifs and the …
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