NK cell heparanase controls tumor invasion and immune surveillance

EM Putz, AJ Mayfosh, K Kos… - The Journal of …, 2017 - Am Soc Clin Investig
NK cells are highly efficient at preventing cancer metastasis but are infrequently found in the
core of primary tumors. Here, have we demonstrated that freshly isolated mouse and human
NK cells express low levels of the endo-β-D-glucuronidase heparanase that increase upon
NK cell activation. Heparanase deficiency did not affect development, differentiation, or
tissue localization of NK cells under steady-state conditions. However, mice lacking
heparanase specifically in NK cells (Hpsefl/fl NKp46-iCre mice) were highly tumor prone …

NK cell heparanase controls tumor invasion and immune surveillance

EM Putz, AJ Mayfosh, K Kos, DS Barkauskas… - The Journal of Clinical …, 2024 - jci.org
NK cells are highly efficient at preventing cancer metastasis but are infrequently found in the
core of primary tumors. Here, have we demonstrated that freshly isolated mouse and human
NK cells express low levels of the endo-β-D-glucuronidase heparanase that increase upon
NK cell activation. Heparanase deficiency did not affect development, differentiation, or
tissue localization of NK cells under steady-state conditions. However, mice lacking
heparanase specifically in NK cells (Hpsefl/fl NKp46-iCre mice) were highly tumor prone …
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