NRF2 as a regulator of cell metabolism and inflammation in cancer
Carcinogenesis, 2020•academic.oup.com
Nuclear factor erythroid 2‐related factor 2 (NRF2) is a master transcriptional regulator of
genes whose products defend our cells for toxic and oxidative insults. Although NRF2
activation may reduce cancer risk by suppressing oxidative stress and tumor-promoting
inflammation, many cancers exhibit elevated NRF2 activity either due to mutations that
disrupt the negative control of NRF2 activity or other factors. Importantly, NRF2 activation is
associated with poor prognosis and NRF2 has turned out to be a key activator of cancer …
genes whose products defend our cells for toxic and oxidative insults. Although NRF2
activation may reduce cancer risk by suppressing oxidative stress and tumor-promoting
inflammation, many cancers exhibit elevated NRF2 activity either due to mutations that
disrupt the negative control of NRF2 activity or other factors. Importantly, NRF2 activation is
associated with poor prognosis and NRF2 has turned out to be a key activator of cancer …
Abstract
Nuclear factor erythroid 2‐related factor 2 (NRF2) is a master transcriptional regulator of genes whose products defend our cells for toxic and oxidative insults. Although NRF2 activation may reduce cancer risk by suppressing oxidative stress and tumor-promoting inflammation, many cancers exhibit elevated NRF2 activity either due to mutations that disrupt the negative control of NRF2 activity or other factors. Importantly, NRF2 activation is associated with poor prognosis and NRF2 has turned out to be a key activator of cancer-supportive anabolic metabolism. In this review, we summarize the diverse roles played by NRF2 in cancer focusing on metabolic reprogramming and tumor-promoting inflammation.
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